Exploring Latin America's Largest Cities Mexico City, pictured here with the Ángel de la Independencia in the foreground, is among the largest and most influential cities in Latin America. (more) Largest Cities in Latin America Written by Katie Angell Katie Angell is Associate Editor at Encyclopedia Britannica, covering topics related to Latin America. She holds an MA from Vanderbilt University and is pursuing a PhD in Political Science. Katie Angell Fact-checked by Britannica Editors Encyclopaedia Britannica's editors oversee subject areas in which they have extensive knowledge, whether from years of experience gained by working on that content or via study for an advanced degree.... Britannica Editors Last updated May 13, 2026 •History Latin America, which generally includes Mexico, Central America, South America, and the Spanish- and Portuguese-speaking countries of the Caribbean, is one of the most urbanized regions in the world, with more than four-fifths of its population living in cities, according to World Bank data—well above the global average. As a result, several of its metropolitan areas rank among the largest on earth. For example, Mexico City and São Paulo each have metropolitan populations of more...

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