peripheral immune tolerance Ask the Chatbot a Question More Actions Share Share Share to social media Facebook X URL https://www.britannica.com/topic/peripheral-immune-tolerance Feedback Corrections? Updates? Omissions? Let us know if you have suggestions to improve this article (requires login). Feedback Type Select a type (Required) Factual Correction Spelling/Grammar Correction Link Correction Additional Information Other Your Feedback Submit Feedback Thank you for your feedback Our editors will review what you’ve submitted and determine whether to revise the article.

　　External Websites Ask the Chatbot a Question Written by Written by Kara Rogers Kara Rogers is the senior editor of biomedical sciences at Encyclopædia Britannica, where she oversees a range of content from medicine and genetics to microorganisms. She joined Britannica in 2006 and... Kara Rogers Fact-checked by Fact-checked by The Editors of Encyclopaedia Britannica Encyclopaedia Britannica's editors oversee subject areas in which they have extensive knowledge, whether from years of experience gained by working on that content or via study for an advanced degree.... The Editors of Encyclopaedia Britannica Last Updated: Oct. 17, 2025 •Article History Table of Contents Table of Contents Ask the Chatbot peripheral immune tolerance, the set of mechanisms that prevent immune cells—especially T cells and B cells—from attacking the body’s own tissues after the cells have matured and left so-called central tolerance sites—namely, the thymus and bone marrow. By maintaining control over self-reactive lymphocytes that escaped central tolerance, peripheral immune tolerance serves as a critical protective boundary against autoimmunity. In peripheral tissues, immune tolerance is regulated through several complementary processes. Some self-reactive cells become anergic, meaning...

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