last universal common ancestor biology Actions Cite verifiedCite While every effort has been made to follow citation style rules, there may be some discrepancies. Please refer to the appropriate style manual or other sources if you have any questions. Select Citation Style MLA APA Chicago Manual of Style Copy Citation Share Share Share to social media Facebook X URL https://www.britannica.com/science/last-universal-common-ancestor Give Feedback Feedback Corrections? Updates? Omissions? Let us know if you have suggestions to improve this article (requires login). Feedback Type Select a type (Required) Factual Correction Spelling/Grammar Correction Link Correction Additional Information Other Your Feedback Submit Feedback Thank you for your feedback Our editors will review what you’ve submitted and determine whether to revise the article.

　　Print print Print Please select which sections you would like to print: Table Of Contents Cite verifiedCite While every effort has been made to follow citation style rules, there may be some discrepancies. Please refer to the appropriate style manual or other sources if you have any questions. Select Citation Style MLA APA Chicago Manual of Style Copy Citation Share Share Share to social media Facebook X URL https://www.britannica.com/science/last-universal-common-ancestor Feedback Also known as: LUCA Written by L. Sue Baugh L. Sue Baugh is a writer and editor who works in the educational, business, and science/medical fields. L. Sue Baugh Fact-checked by The Editors of Encyclopaedia Britannica Encyclopaedia Britannica's editors oversee subject areas in which they have extensive knowledge, whether from years of experience gained by working on that content or via study for an advanced degree. They write new content and verify and edit content received from contributors. The Editors of Encyclopaedia Britannica Last Updated: Aug 5, 2024 • Article History Table of Contents last universal common ancestor (LUCA), microorganism proposed to be the genetic ancestor of all domains of life—namely, the Bacteria, Archaea, and Eukarya. The idea that all species descend from a common ancestor was first proposed in the 19th century, by naturalists Jean-Baptiste Lamarck and Charles Darwin. In the following century scientists began to decode the genetic sequences and biochemical pathways of life, gaining insight into evolutionary history and leading to the concept of the last universal common ancestor (LUCA). Today the ongoing search for—and possible elucidation in 2024 of—LUCA has helped expand scientific understanding of the tree of life.

　　LUCA, as distinguished from an entity representing the origin of life on Earth, is now thought to have been a complex life-form that evolved to become a node at the root of the tree of life, from which the prokaryotes (bacteria and archaea) are derived. The search for such a life-form began in earnest in the 1990s, fueled by research conducted by scientists Carl Woese and George Fox, who in the 1970s devised the classification of all life into three lines of descent, on the basis of phylogenetic studies of ribosomal RNA sequences. The three lines were the eubacteria, or the typical bacteria; urkaryotes, or complex eukaryotic cells containing cytoplasm and membrane-bound organelles; and archaebacteria, or methanogenic bacteria, which possess unique metabolic systems and have no clear relation to bacteria or eukaryotic cells.

　　At the base of the tree of life that branched into the bacteria, archaebacteria, and eubacteria rested an as yet unknown common ancestor. Woese and Fox suggested that such an ancestor would have been a relatively simple entity, possibly a primitive progenote, an entity that represented an early stage of cellular organization and served as an evolutionary link between genotype and phenotype. In 1990 Woese and colleagues proposed a formal classification of life into three domains, designated Bacteria, Eukarya, and Archaea, and advanced the concept of LUCA. Woese’s idea for the division of life into three distinct lineages was driven by emerging molecular data. That data helped to begin a move away from sole dependence on classical phenotypic comparisons, which were largely unreliable for understanding complex evolutionary relationships.

　　Various approaches have been employed in the search for LUCA. In some instances, the focus has been on isolating gene sequences that are shared among species and therefore suggest a common ancestor. For example, humans and chimpanzees share about 98 percent of their gene sequences, which is a strong indication that both species arose from a common ancestor. LUCA may also have left a mark within the genetic material of modern organisms. In 2016 researchers compared the sequences of some six million protein-coding genes from prokaryotic organisms; 355 of the sequences were concluded to have likely originated from LUCA.

　　Shared biochemical processes within cells have also been investigated. Research has shown, for instance, that species in Bacteria, Archaea, and Eukarya have conserved core metabolic pathways for the synthesis of amino acids, lipids, nucleotides, sugars, and organic cofactors. Because it is highly unlikely that organisms in the three domains would have developed identical pathways independently, scientists suggest that LUCA must have laid down this original metabolic core.

　　Other research has shown that eukaryotic cells contain contributions from prokaryotes of both Bacteria and Archaea. Among those contributions are mitochondria (energy-producing organelles) and metabolic mechanisms. These observations suggest a role for horizontal gene transfer, in which genes are transmitted across different genomes, in the evolution of the three domains. Horizontal gene transfer allows organisms to acquire diverse features that they cannot acquire from the vertical transmission of genetic material along a family line.

　　Origin and nature Get a Britannica Premium subscription and gain access to exclusive content. Subscribe Now The origin in place and time for the emergence of LUCA remains a matter of debate. In the 1990s the most recent common ancestor was thought to have first emerged between about 3.2 and 3.8 billion years ago. In 2023 research pointed to an origin of 4.32 to 4.52 billion years ago, only a few million years after Earth became stable enough to support life. Eukaryotes emerged after bacteria and archaea and thus are younger in terms of evolutionary age, indicating that the Bacteria and Archaea domains diverged from LUCA, while Eukarya presumably developed from the fusion of genes and cellular mechanisms that originated in the other two domains.

　　The nature of LUCA itself is also unknown. Gene sequences and chemical and metabolic mechanisms traced to LUCA suggest that it was a thermophilic, or heat-loving, microorganism that lived near deep-sea vents. The high temperatures and rich chemical resources at such vents would have provided an ideal environment for the origination and survival of LUCA, which, given the elucidated metabolic requirements and byproducts of LUCA, may have been part of a larger ecosystem. Research has suggested that this most recent common ancestor was probably more prokaryotic than progenotic, in contrast to Woese and Fox’s initial conception.

　　Research published in 2024 has inferred that LUCA was in existence about 4.2 billion years ago and was a prokaryotic anaerobic acetogen (a microorganism that generates acetate as a product of anaerobic respiration). Furthermore, this research has suggested that LUCA possessed genetic elements representing a primitive immune system and has lent support to the idea that LUCA was part of an established ecosystem.